Dr. Randolph's 2 oz Natural Estro-Fem cream is a bio-identical formulation of Estriol. This means that the molecules of Estriol suspended in the cream have exactly the same molecular structure as those produced by the human body. The Estriol molecule in Dr. Randolph's Natural Estro-Fem Cream is incased within a liposomal delivery system. This is critical because, as the many layers of the oily globule of liposome melt away like a snowball, the hormones are dispersed continuously through the skin for up to 12 hours. Estriol is one of the three principal estrogens that are produced by the body. Research has shown to have benefits for breast health, bone density, heart health, multiple sclerosis, postmenopausal urinary tract health and vaginal dryness. If you are on estrogen supplementation of any kind, bioidentical or synthetic, you should always use bioidentical progesterone every day. When not balanced by adequate progesterone, excess estrogen levels can stimulate proliferation (or cell growth). Unchecked cell growth can be a precursor for breast and uterine cancers. Ingredients: Deionized Water, Caprylic/Capric Triglyceride, Polyacrylamide, C 13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Caprylyl Glycol, Sorbic Acid, Grapefruit Seed Extract, SD Slcohol, Aloe Barbadensis Leaf Juice, Tocopheryl Acetate, Estriol Usage: Topically apply two fully primed pumps to skin twice daily.